Tolcapone
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB00323 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 70 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | Rasmussen subacute encephalitis | KG + DL |
| 2 | myelitis | KG + DL |
| 3 | PLA2G6-associated neurodegeneration | KG + DL |
| 4 | transaldolase deficiency | KG + DL |
| 5 | fructose-1,6-bisphosphatase deficiency | KG + DL |
| 6 | Lewy body dementia | KG + DL |
| 7 | X-linked intellectual disability-ataxia-apraxia syndrome | KG + DL |
| 8 | polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis | KG + DL |
| 9 | X-linked intellectual disability-cerebellar hypoplasia syndrome | KG + DL |
| 10 | paralysis agitans, juvenile, of Hunt | KG + DL |
| 11 | atypical glycine encephalopathy | KG + DL |
| 12 | CLCN4-related X-linked intellectual disability syndrome | KG + DL |
| 13 | congenital disorder of glycosylation with defective fucosylation | KG + DL |
| 14 | Charcot-Marie-Tooth disease, demyelinating, type 1G | KG + DL |
| 15 | X-linked intellectual disability-spastic quadriparesis syndrome | KG + DL |
| 16 | intellectual disability, X-linked, syndromic | KG + DL |
| 17 | hydrocephaly-cerebellar agenesis syndrome | KG + DL |
| 18 | X-linked cerebral-cerebellar-coloboma syndrome syndrome | KG + DL |
| 19 | syndromic X-linked intellectual disability Chudley-Schwartz type | KG + DL |
| 20 | X-linked spasticity-intellectual disability-epilepsy syndrome | KG + DL |
| 21 | Paganini-Miozzo syndrome | KG + DL |
| 22 | NAA10-related syndrome | KG + DL |
| 23 | lissencephaly type 1 due to doublecortin gene mutation | KG + DL |
| 24 | progressive supranuclear palsy-corticobasal syndrome | KG + DL |
| 25 | X-linked intellectual disability, Stocco dos Santos type | KG + DL |
| 26 | X-linked intellectual disability-hypotonia-movement disorder syndrome | KG + DL |
| 27 | Prieto syndrome | KG + DL |
| 28 | MED12-related intellectual disability syndrome | KG + DL |
| 29 | retinal dystrophy with or without extraocular anomalies | KG + DL |
| 30 | intellectual developmental disorder, X-linked, syndromic, Hackmann-Di Donato type | KG + DL |
| 31 | myopia 26, X-linked, female-limited | KG + DL |
| 32 | Basilicata-Akhtar syndrome | KG + DL |
| 33 | X-linked intellectual disability-craniofacioskeletal syndrome | KG + DL |
| 34 | holoprosencephaly 13, X-linked | KG + DL |
| 35 | X-linked intellectual disability with hypopituitarism | KG + DL |
| 36 | X-linked intellectual disability-precocious puberty-obesity syndrome | KG + DL |
| 37 | myopia X-linked | KG + DL |
| 38 | X-linked intellectual disability-acromegaly-hyperactivity syndrome | KG + DL |
| 39 | schizophrenia | KG + DL |
| 40 | lethal infantile mitochondrial myopathy | KG + DL |
| 41 | syndromic myopia | KG + DL |
| 42 | hydranencephaly (disease) | KG + DL |
| 43 | Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome | KG + DL |
| 44 | febrile infection-related epilepsy syndrome | KG + DL |
| 45 | polycystic kidney disease 3 with or without polycystic liver disease | KG + DL |
| 46 | perioral myoclonia with absences | KG + DL |
| 47 | Lennox-Gastaut syndrome | KG + DL |
| 48 | cryptogenic late-onset epileptic spasms | KG + DL |
| 49 | photosensitive occipital lobe epilepsy | KG + DL |
| 50 | atypical childhood epilepsy with centrotemporal spikes | KG + DL |
(Showing top 50 of 70 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.